In vitro Anticancer studies of new synthetic Hybrid Quinolines

Abdallah, Aalaa Khaled; Rizk, Sameh Ahmed; Aly, Mohamed R

doi:10.21608/ajbas.2024.313668.1225

In vitro Anticancer studies of new synthetic Hybrid Quinolines

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of Science, Port Said University, Port Said 42526, Egypt.

² Chemistry Department, Faculty of Science, Ain Shams University, Abassia, Cairo 11566, Egypt.

10.21608/ajbas.2024.313668.1225

Abstract

Three novel synthetic Hybrid Quinolines (6-8) with different tags on the triazole moiety were synthesized via copper-catalyzed azide alkyne cycloaddition (CuAAC) reaction which gave high yields of the products without undesirable byproducts, the so-called click reaction, between 4-Azido-2,6-dimethylquinoline 2 and three different terminal alkynes (3-5). The synthesized 1,4-hybridized-1,2,3- triazoles were characterized using various spectroscopic tools such as IR, MS, and multi NMR techniques (1H NMR ,13C NMR, COSY, HSQC and DEPT-135°) to elucidate their structure and the spectral analysis of the compounds was in agree with the proposed structures. The cytotoxicity of these compounds was assayed using MTT colorimetric technique against mammalian breast cancer (MCF-7) and prostate cancer (PC-3) cell lines using Doxorubicin (Dox.) as positive control. Compound 7 was the most active against both cell lines and specially displayed promising cytotoxic activity against PC-3 cell line as it was 17% (0.2-fold) more active than Dox.,While conjugate 6 was much less active than doxorubicin in both cell lines.

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