Hepato-renal and splenic cytotoxic effects of American cockroach Periplaneta americana hemolymph in Solid Ehrlich carcinoma-bearing mice

Osman, Esraa Gamal; Tawfik, Mohamed Mahmoud; Ahmed Abdel Rahman, Mohamed; Hassan, Mohamed Kamel; Khalaf, Ahmed

doi:10.21608/ajbas.2023.227694.1182

Hepato-renal and splenic cytotoxic effects of American cockroach Periplaneta americana hemolymph in Solid Ehrlich carcinoma-bearing mice

Document Type : Original Article

Authors

¹ biotechnology ,Zoology Department ,Faculty of Science, Port Said University

² Zoology Department, Faculty of Science, Port Said University, Port Said, Egypt

³ Assistant Professor of Physiology Zoology Department Suez Canal University

⁴ Faculty of Science, Port Said University, Appointed visiting professor at the Center for Genomics, Zewail City for Science and Technology

⁵ Department of Zoology, Faculty of Science, Port Said University

10.21608/ajbas.2023.227694.1182

Abstract

Cancer is one of the communal reasons -for death worldwide. Periplaneta americana (P. americana) hemolymph revealed a wide range of biological activities, including antibacterial, anticancer, antiviral, and antiinflammation. Using histopathological approaches, this study was conducted to evaluate the safety of P. americana hemolymph by investigating its toxicological effects on liver, kidney, and spleen tissues of Solid Ehrlich carcinoma cells bearing mice. The results showed remarkable inflammatory and necrotizing toxic effects of P. americana hemolymph on mice's liver with no remnant of liver tissues. It also induced tubular necrosis of renal tubular kidney tissue, and lymphoid hyperplasia with significant congested red pulp in spleen tissue after treatment for 14 days. These findings concluded that P. americana hemolymph has prominent hepato-renal and splenic cytotoxic effects of Solid Ehrlich carcinoma cells bearing mice. The histopathological data of P. americana hemolymph should be considered while using these materials in the discovery and development of anticancer agents.

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