Document Type : Original Article
Authors
1
chemistry department,faculty of science,port said university
2
chemistry department,faculty of science, mansoura university, mansoura,egypt
3
plant protection research institute,agriculture research center,12618,Egypt
4
Chemistry Department, Faculty of Science, Port Said Univeristy, Egypt.
5
Chemistry department,faculty of science,port said university,port said ,egypt
Abstract
Methanolic extract of the aerial part of Moltkiopsis ciliata (Forssk.) (Boraginaceae) was obtained and successively fractionated into two main fractions (hexane fraction and methylene chloride fraction), which were phytochemically investigated using GC/MS technique. The whole of thirty-five compounds were identified and quantified. They are belonging to different classes; twenty-one acetogenins (Fat derivatives), six shikimates, five terpenes and one sterol. Beside the characterization of the volatile compounds profile, β-amyrin was isolated and identified using chromatographic and spectral techniques. The methanolic extract and two fractions were screened for their cytotoxic activity against breast cancer cell line MCF7 and hepatocellular carcinoma cell line HepG2. The methylene chloride fraction was proved to be the most potent cytotoxic agent. The major phyto-components of the two fractions were known by their various biological activity as antimicrobial, antiprofilative, antioxidant, Hypocholesterolemic, Antiandrogenic flavor, Nematicide, pesticides, anti-inflammatory, Hemolytic and have significant pharmaceutical importance especially as anticancer agents. The bioactive volatile constituents recommended phytopharmaceutical importance of the plant
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