Evaluation Gene Expression of Kinase Insert Domain (KDR) as Prediction of Preeclampsia with Novel Biomarkers

Document Type : Original Article

Authors

1 Department of Chemistry, Faculty of Science, Port Said University

2 Department of Clinical Biochemistry, Faculty of Medicine

3 Department of Gynocology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. .

4 Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt.

5 Insurance of health

Abstract

Preeclampsia (PE) is the complexity the case of pregnancy with an indication of the presence of defective placentas, and inadequate blood supply to the placenta defect and endothelial dysfunction .the aim of study. The variation between endothelial growth factor angiogenesis (VEGF), placental growth factor (PlGF) and their receptors kinase domain that contains the receptor (KDR) and tyrosine kinase 1 (Flt-1) plays a valuable role in the pathophysiology of PE .We conducted a cross-sectional study of 50 women with Preeclampsia: 25 women with mild PE, and 25 patients with severe PE. While 24 pregnant women work normally with age as a control group. placental mRNA gene expression of KDR was measured using real time PCR ( RT/PCR),The mean of KDR expression was statistically significantly higher in the control group compared to any of the PE groups (p < /p>

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